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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARHGEF7 All Species: 8.18
Human Site: Y57 Identified Species: 20
UniProt: Q14155 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14155 NP_001106983.1 803 90012 Y57 P G T I E K V Y P E P R S E S
Chimpanzee Pan troglodytes XP_509742 901 100045 Y134 P E E E K R V Y P E P R S E S
Rhesus Macaque Macaca mulatta XP_001083544 776 87430 I45 G V V L C K L I N R L M P G S
Dog Lupus familis XP_542671 952 105982 V126 E R L A G A A V V A P R A C A
Cat Felis silvestris
Mouse Mus musculus Q9ES28 862 97037 Y57 P G T I E K V Y P E P R N E S
Rat Rattus norvegicus O55043 646 73122
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514136 771 86999 V39 K C S L K N G V V L C K L I N
Chicken Gallus gallus Q5ZLR6 764 85889 T33 D P E E F L K T S L K D G T V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001116707 858 96627 I57 P G T T D K I I Q D P K N D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784106 581 64090
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.2 54.9 73.3 N.A. 85 66.3 N.A. 57 56.5 N.A. 69.6 N.A. N.A. N.A. N.A. 30.8
Protein Similarity: 100 81.9 70.8 77 N.A. 87.8 71.1 N.A. 72.9 72.7 N.A. 79.8 N.A. N.A. N.A. N.A. 45.2
P-Site Identity: 100 66.6 13.3 13.3 N.A. 93.3 0 N.A. 0 0 N.A. 40 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 80 26.6 26.6 N.A. 100 0 N.A. 33.3 0 N.A. 80 N.A. N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 10 10 0 0 10 0 0 10 0 10 % A
% Cys: 0 10 0 0 10 0 0 0 0 0 10 0 0 10 0 % C
% Asp: 10 0 0 0 10 0 0 0 0 10 0 10 0 10 0 % D
% Glu: 10 10 20 20 20 0 0 0 0 30 0 0 0 30 0 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 30 0 0 10 0 10 0 0 0 0 0 10 10 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 20 0 0 10 20 0 0 0 0 0 10 0 % I
% Lys: 10 0 0 0 20 40 10 0 0 0 10 20 0 0 0 % K
% Leu: 0 0 10 20 0 10 10 0 0 20 10 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 0 10 0 0 0 20 0 10 % N
% Pro: 40 10 0 0 0 0 0 0 30 0 50 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Q
% Arg: 0 10 0 0 0 10 0 0 0 10 0 40 0 0 0 % R
% Ser: 0 0 10 0 0 0 0 0 10 0 0 0 20 0 50 % S
% Thr: 0 0 30 10 0 0 0 10 0 0 0 0 0 10 0 % T
% Val: 0 10 10 0 0 0 30 20 20 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 30 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _